Lippincott dating meds when opened
Stability tests of the “sealed” group were performed after 4 weeks, while for the group in which the bottles were shaken and opened twice daily, stability tests were performed weekly.
Chemical stability was determined by high performance liquid chromatography and p H, and microbial stability was determined by microbial limit tests according to pharmacopeias.
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However, mold and yeast counts exceeded the limits during the 2nd week in the “opened daily” group.
Extemporaneous 0.1% morphine HCl oral solutions prepared in an ISO Class 8 clean room have a beyond-use date of 4 weeks in HDPE bottles when refrigerated.
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